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Chrizum said:

N20 has been used for ages at the dentist for local sedation and has no negative effects whatsoever. The biggest risk when consuming it recreationally is hurting your head from losing your balance and falling down.

I'd say, when rating on health risks alone, marijuana and MDMA are in the same ball park when used wisely. Speed, alcohol, cocaine, heroin, crack, crystal meth; those are the ones you should watch out for when you don't want to risk your health.

Yea, the key thing with drugs is moderation.  If you abuse any drug (even marijuana) then there will be negative side effects.  Like being a little lazy all day if you wake up and smoke nonstop.  However, if you work your ass off and smoke a bowl after work (to relax) then you are using drugs in a better way.  If people had more will power then they could easily use their drug of choice more effectively (less drug for the same high/use them less).  The problem I see with drug abuse is that people have allowed their mind to be too weak.  I'll use cigarettes as an example.  Most people that smoke cigs will tell you they really want a cigarette because they are stressed out at the moment (blaming work, life, etc).  Instead of realizing that it is the lack of nicotine in the body (nicotine telling your body to obtain more) that is actually causing the most stress.  Luckily, I've been able to put down cigs myself considering I know marijuana is a lot safer, healthier, and has a way better feeling than a cig buzz.