gta 4 easily. wont even be close. brawl and wii fit have will have great runs though. also lbp could take off, but i dont think it has enough time in 2008 to make a good run (due to the fact that it needs a way bigger install base, like 20-30 million, to make a run, and that it will not boom and bust like most games so it will sell really well in 2009)