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Without even going into why they are totally different, one factor really sticks out. Unlike Final Fantasy, Mass Effect has not been able to become a worldwide success. While ME is very popular in the west it has not made much of a dent in Japan. Of course it doesn't help that the platform it started out on is also a non factor in Japan.

So while it is theoretically possible that it may one day become more like FF, at this stage it's like comparing apples and oranges.