My Game Boy Color got corrupted by a device called a Brain Boy, which was basically a hacking device for Pokemon Gold and Silver, such that no games would run in the GBC without the Brain Boy in place, and if i tried, all their save data would be erased
Wii lost its laser and now had its motherboard go bad on me, though me shipping it back and forth to college so many times can't have helped the motherboard
Monster Hunter: pissing me off since 2010.