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2D side-scrollers, like, say, Mega Man. Just no shit voice acting or gameplay that feels like slow motion. The PSP Mega Men can be used as guidelines on what not to do.

GTA.

A Team Ico game. Probably wouldn't fit well on a handheld, but WHAT. THE FUCK. EVER.

Twisted Metal. (This one would definitely fit well on the system.)

New IPs should be a given.