| Michael-5 said: Drake - Uncharted 2 - Voice actor from Firefly |
The actor from Firefly you are thinking of is Nathan Fillion, who is not the voice of Drake; that's Nolan North. 
OT: Really, too many to think of but the ones who come to mind are:
Link from the Zelda series: Love that he never speaks; instead people who talk to him just respond as if he's answering their questions. Even when full voice acting is eventually introduced in a Zelda game, I hope this never changes.
Hiryu from Strider: Just badass!
Samus from the Metroid series: All appearances except Other M, in which I didn't care for her character.
I also really like Alucard from Castlevania: Symphony of the Night (very cool character, although his voice acting sucks, but fortunately it's brief) and Drake from the Uncharted series and Solid Snake from the Metal Gear series; they're great characters with excellent voice acting.
