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thranx said:

Pain killers tend to tell your body to ignore the pain and since you may not feel the pain chances are you will continue to do what is causing the pain and thus make it worse or still have the pain when the pain killer wears off. If you are in pain it is best to treat the cause not the symptoms. That is the problem with most medicine, it cures sympotns not sources of illness/pain.

The most effective way is, for example, when you feel a headache coming and you know it's going to hit regardless of what you'll do next. Take a pill and stop what you're doing that's causing the headache. The pill will stop the headache and give your body enough time to recover so that when the pill wears out, you won't get the headache at all.