Dark Pirate Commando - Metroid Prime 2: Those are the ones who can become invisible and can be stupid frustrating to take down.
Birds - Ninja Gaiden: It needed to be said.
Regenerator - Resident Evil 4: Nothing worse than just trying to snipe that last damn Plagus from these dudes and getting ripped apart. They look awesome though.
Lakitu - Super Mario 3: He never dies and has a endless supply of spiked death to throw at you. Scary.
The Orange button - Guitar Hero Series: Not really an enemy in the traditional sense, but it's my worst enemy. DAMN YOU MAKING ME USE MY PINKY!
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