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I have the same MGS4 bundle.  Been running fine (though my fans do kick up when playing the game vs. playing SSFIV) even through multiple hour sessions.  Of course I vaccuum my PS3 every 2-3 weeks, so that may help.  If you're just gonna sit any worry that a game is gonna kill your system, why play any games?  It sucks if the system dies but at least you will have had fun playing it :)