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Mithos Yggdrasill/Presea Combatir from Tales of Symphonia: Anyone who played it (which unfortunately wasn't as many people as it should have been) knows why.

Mario: Having to save a stupid bitch who gets off on being kidnapped by a huge turtle and resulting in him having no time to be a plumber, which means he needs to smash his head into bricks to get money. He has to resort to doing drugs in order to survive since that way he can live when he gets hit by all those pesky bullet bills or he can throw a fireball at a piranha plant that is blocking the pipe to get to the next area. It's just such a hard life D:

Also Luigi: for getting the shaft in most Mario games and living in a run down house with ghosts in it.