pacman91 on 10 March 2011
I find defense grid: the awakening to be highly enjoyable even w/o a mouse. It's a fairly deep tower defense game.
Are you done with turn based in general? Europa Universalis III is similar to Civ 4, but more along the line of risk.
Also vvvvvv and trackmania nations forever(free) are great. All can be found on steam.
