Probably Skyward Sword and maybe Last Guardian. Oh and probably ME3 like you said. Maybe Ghost Recon Future soldier?
2012 should/could be amazing for games:
- Zelda: SS (if its not 2011)
- Last Guardian (if not 2011)
- Mass Effect 3 (if not 2011)
- Ghost Recon (if not 2011)
- Agent? (this game is starting to look like vapourware. Better be some news at E3)
- GTA5? (come on the last one was 2008! We're way overdue for another one)
- GT6? (probably a stretch, but could be late 2012 or early 2013)
- Halo game?
- Bioshock Infinite
- FFv13