I'd argue it wasn't "pick up and play" enough.
Common thing between LBP, NSMB, and Mario Kart? You can get in and start playing with nary a load screen at all. That is key for a game to be popular amongst a more casual audience. Accessibility and ease of use. Excruciatingly long load times and an unintuitive menu can kill a game like this.
Plus, I wouldn't exactly call the characters in MNR charming. They just looked goofy to me, and don't have the appeal of Sackboy or Nintendo's mascots.







