Sakura's death i'd say is a given, but i tend to ship NaruHina, so i'm figuring it has to go that way. I'd rather an ending where Sasuke dies, though i agree he'll probably die redeeming himself in a final struggle against Kabuto/Orochimaru. I'd hazard a guess that Kabuto could end up taking over Madara's body in a version of what Orochimaru had planned to do with Sasuke
I'm nowhere near caught up, though. I've just been leeching off spoilers, and in the anime i'm currently at the Jiraiya-Pain fight, though i have a good idea of the narrative between then and the current manga

Monster Hunter: pissing me off since 2010.







