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I failed to save Meryl in my first playthrough of Metal Gear: Solid.  I spent many hours trying to atone for that failure.  Killing Sniper Wolf made me feel really bad, too.  Wasn't able to bring myself to gun down the innocents at the airport in Modern Warfare 2.  Couldn't watch the Rachni Queen die in Mass Effect when I played the Renegade path on my second playthrough.  I play my games with a fully armed and operational conscience.