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Slimebeast said:

Don't fool yourself. Skyrim is by far the biggest favorite.

Uncharted 3 will come closest quality/review-wise but it will suffer from feeling "more of the same", and it suffers a little from being exclusive.

Mass Effect 3 will get superb reviews and is multiplatform but suffers from an early year release and memory fade.

Meanwhile there's a whole 5.5 years between the last Elder Scrolls (Oblivion who also won Spike's GOTY) and Skyrim.

Actually ME3 most likely won't release until late 2011...and its going to be a damn fine game.