Really it doesn't matter whether Sony is revealing a PS3 exclusive or having an "exclusive PS3 reveal". The fact that it's Sony doing the revealing all but guarantees that it is a Sony game, which would be exclusive anyway.
Most likely it's Uncharted 3 since Uncharted 2 was announced at the VGAs a year after the first Uncharted was released which would put an Uncharted 3 reveal right on schedule.
Other possibilities include Starhawk, Sly 4, and Agent from Rockstar North.