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ameratsu said:

This is probably a silly question, but what's the hardest class to use for an insanity playthrough? I played an Infiltrator for my Hardcore playthrough (with Reave as my special ability) and it was honestly easy once I was able to use the anti-material rifle. 

Sorry I didn't see this earlier.

None of the classes are really hard when you learn how to use them properly - not a single one of them even needs a bonus power, saving maybe the Engineer.

Most people tend to have the hardest time adjusting to a Vanguard, but that usually only lasts until you really get comfortable with Charge.