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ameratsu said:

This is probably a silly question, but what's the hardest class to use for an insanity playthrough? I played an Infiltrator for my Hardcore playthrough (with Reave as my special ability) and it was honestly easy once I was able to use the anti-material rifle. 


The answer will probably vary between each individual.

In my experience, the vanguard has a difficult time in the early parts of the game (because you don't have the powers and upgrades to survive easily in close-range yet) but once you get to Horizon and onward, the vanguard class starts becoming a monster, where you'll start charging Harbingers, Scions, and even Mechs.

I feel the adept is also similar, in that it has a bit more of a difficult time in the early parts of the game (since the cooldown of your abilities aren't shortened yet), but becomes an absolute controlling powerhouse towards the latter game.  You'll often hear people complain about why powers can't work on enemies with defenses (armor or shields), but honestly, a few shots with your weapons (or with the help of your allies) is enough to strip defenses and start throwing out singularity/warp explosions.

In my opinion, the easiest class by far is the soldier.  Soldiers excel at pretty much any combat range, and Adrenaline Rush can be incredibly powerful with several weapons.

I will admit that the only difficulty level that I have played Mass Effect 2 on is insanity (thankfully you don't have to unlock it like how you had to in the first game), so I don't know how the classes differ on easier difficulty levels.