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Code Veronica was (and still is) the only full blown Resident Evil that I only played through once.  I probably played through RE 1 & 2 over ten times each.  I beat RE3 twice.  I beat RE4 several times on the GC, turned around and beat it three more times for the Gamecube.  And RE5, I play through all the time.  In fact, I was playing it earlier this afternoon.  So, you're asking if my most played RE is favored over my absolute least played RE.

Gotta go with RE4 by a landslide.