Just because I like making lists, here are my PS3 and Wii picks:
PS3
Uncharted 2: Among Theives
Batman: Arkham Asylum
Metal Gear Solid 4
Heavy Rain
Valkyria Chronicles
Little Big Planet
Uncharted: Drakes Fortune
Super Stardust HD
Heavenly Sword (started playing it again, last night!)
inFamous
And Wii:
Super Mario Galaxy 2
Mario Kart Wii
Super Mario Galaxy
Metroid Prime 3: Corruption
Resident Evil 4: Wii Edition
New Super Mario Bros. Wii
Super Smash Bros. Brawl
Wario Ware: Smooth Moves
Punch Out!!
Zack and Wiki
(If I didn't have Zelda: TP for the Gamecube, it would probably be up there in the top three)