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I doubt we'll see games where we're forced to turn off 3D. The gameplay will occur on the top screen, not the bottom. We can still use the touch screen to control what happens on top. It's not that difficult.

For a game like Trauma Center, you can use the touch screen while a reticle (or a scapple for ex.) appears on the top screen.  And to perform an action (incision), use one of the shoulder buttons.

The days of gamaeplay occuring on both screens are over. Like I said earlier, don't expect action to hop onto the bottom.