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I'm pushing 3DS off to the side, because holy fuck it would dominate my list almost as hard as it's going to dominate the market... and this is only for stuff actually at E3...

 

1. Dragon Quest IX: Sentinels of the Starry Skies (DS, Nintendo / Square Enix / Level-5)

2. The Legend of Zelda: Skyward Sword (Wii, Nintendo)

3. Marvel Vs. Capcom 3: The Fate of Two Worlds (360, Capcom)

4. Child of Eden (360, Ubisoft / Q? Entertainment)

5. Kirby's Epic Yarn (Wii, Nintendo / Sora / Good Feel)

6. Metroid: other M (Wii, Nintendo / Team Ninja)

7. Vanquish (360, SEGA / Platinum Games)

8. Portal 2 (360, Valve)

9. Final Fantasy: The 4 Heroes of Light (DS, Square Enix / Matrix Software)

10. Lost in Shadow (Wii, Hudson)