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I always go for the game's default difficulty level.  Normal/Medium it is.

 

Some games I really enjoy, like Uncharted 2, I will replay the game on a higher difficulty level (Crushing).

But more often than not, I don't have the time to replay through a game multiple times, or if I do, it's to enjoy the story again in a faster fashion where I don't go through all the "find everything" process again.  So I don't crank the difficulty higher than on my first run.