What is the most disturbing thing you’ve ever seen in a game?

[Hawk]

d21lewis said:
The intro to "Dead Rising" where the old lady and the little girl are leaving town and the zombies attack. No blood. No gore. No profanity. Just two people in a helpless and hopeless situation. It really got to me.

I must say, those are what get me the most.  The scenes, games, movies that instill a sense of complete hopelessness in the face of imminent doom.  That scene got me as well.  And now that I have young children, anything like that with kids gets me bad.  Because it is horrific to think I could not do something to save my child, and I'm right there