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"The cake is a lie!" ~ Portal (Basically all of Portal quotes are memorable)
"Finish Him" ~ Mortal Kombat
"Snake? Snake! SNAAAAAAAAAAAALE?!?!?" ~ Metal Gear Solid
"Jill, here's a lockpick. It might be handy, if YOU, the master of unlocking, take it with you." and "You were almost a Jill sandwich" ~ Resident Evil
"Not enough cash strangah" "What u buying?" and "What u selling?" ~ Resident Evil 4
"Son of a submariner! " ~ Final Fantasy VI
"I am ERROR" ~ Zelda II
"You spoony bard!" ~ Final Fantasy IV
"YOU'RE WINNER!" ~ Big Rigs

There's a lot more!