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My guess for most likely to be nominated consistently

-Mass Effect 2
-Super Mario Galaxy 2
-Zelda Wii (if it releases)
-GT5
-God of War III

Will likely get some nominations but not as many as those
-Alan Wake
-Fable 3
-Metroid: Other M
-Red Dead Redemption
-The Last Guardian (if it releases)

Has a chance to get a nomination or two
-Bioshock 2
-Final Fantasy XIII (probably not from the bigger places)
-Heavy Rain
-Battlefield 2
- A lot of other not yet released or announced games that will be out at the end of the year.