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This is a difficult question for me to answer and it came down to Uncharted 2 and Mass Effect 2. I have to give the edge to Mass Effect 2 because even after I finished the game I still think about what's happened in the game and what could possibly happen in the final game. I think Bioware did an amazing job of making you like and care about the characters in the game, the save system that's implemented meant that your choices from the first game did matter and no one will have the same experience playing the game. The outcome that you get in the game at certain points and at the end of the game can differ radically depending on the choices that you make and I respect the fact that the developers took the time to do so much work instead of just crafting a linear game that has a set story. The graphics also look great in the xbox 360 version while some developers are having trouble producing hd graphics this game runs in 720p native.

It has everything that is needed to be considered one of the best games this gen if not the best game. Memorable characters, great graphics, good gameplay, and a great story (when combining what happened in mass effect 1 and 2 together)