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Well I voted for Mass Effect 2......but I haven't even beaten that game despite the fact that I own it. My guesses:

God of War 3: Very good reviews but it seems to be more of the same from the franchise. I haven't played it, though.

Bayonetta: Honestly, this may very well be the best game of this generation. It won't win, though. Not high profile enough.

Super Mario Galaxy 2: Not out yet. I don't expect to be blown away like I was with the original. Some of the "freshness" may not be there. I hope I'm wrong.

Metroid: Other M: The game I have the highest hopes for. We'll see........

Halo Reach: The "safe choice" for game of the year from most sites.

Final Fantasy 13: Very fun but very flawed.