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Cactus said:
Heavy usage can cause temporary memory lapses, and if you smoke it unfiltered it can cause throat cancer like cigarettes, cigars and such, but there really has been no definitive proof as to what the plant does to your brain. If anything, the inhalation of the smoke is what makes it unhealthy rather than the contents itself.

This might be taking it off-topic, but I would say that, if your sure it's 100% marajuana with no additions, it is less harmful, both physically and mentally, than alcohol.

Actually, there is some pretty compelling mental proof.

Additionally, filtered is actually worse then straight.  Using a water bong or a cigarette actually is worse for your throat ironically because you need to smoke more to get high.