Can this PC handle these requirements?

[Squilliam]

My suggestion is that if you want this style of PC you're on the right track however you would be far better off with a PC containing an HD 5770 than the GTS 250 on account of the far lower energy useage, DX11 and better performance. These are two better choices in the same price range:

http://www.newegg.com/Product/Product.aspx?Item=N82E16883229157

http://www.newegg.com/Product/Product.aspx?Item=N82E16883227179

But yes, they can both all run the game very smoothly, more than smoothly actually.