I'm quite keen to look into developing games for Natal, I've made a couple of games suitable for XBL and I'm looking forward to microsoft supporting natal in their XNA programming kit so I can make games for it (if they do).
Theres a few ways to hold an xbox controller in one hand so you could use it with Natal, maybe we'll see them releasing a 360mote with a wrist strap like the Wii/Move? Probably including some sort of accelometor sensor the same as sixaxis, wii remote and wii motion plus.
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