http://en.wikipedia.org/wiki/Characters_of_Tales_of_Innocence
Spada is clearly of french design. Nothing very anime in his design at all. Iria is supposed to look like a pirate, which she pulls off pretty well. She has some anime touches to be sure, but nothing like the other games. Ricardo is clearly of American Wild West influence. Ange and Ruca are both English influence.
None of these characters fit standard anime cliches, and I'm not really sure what you are talking about ItsaMii. Either you don't watch much anime at all, or you just didn't remember the characters very well. Clearly the characters are supposed to be European in style. As are the villages whenever you actually get the chance to play it. There is an anime touch to everything, but it wouldn't be Tales without a little anime.
