MULTIPLATFORMS
Mafia 2
At last! A sequel to one of very best (9.3) action games ever made.
Fallout 3
Frontlines: Fuel of War
The Crossing
Source based shooter mixing singleplayer and multiplayer. Developed by Arkane Studios( Arx Fatalis, Dark Messiah of Might and Magic) and Half-Life 2's art director
Heavy Rain
New adventure game from the makers of Indigo Prophecy(one of the best and most unique adventure games of last couple years, Gamespot gave 8,4 and Adventure GOTY in 2005)
Sacred 2
Sequel hack and slash RPG that probably was the best DIablo2-like game(aside from Diablo itself 
) ever released. This time Ascaron is making the game in in full 3D
Rise of the Argonauts
UE 3.0-based action-RPG from Liquid, makers of games like Battle Realms(8.7) and Dragonshard(8.5).
Project Origin
Sequel to FEAR (9.1 from GS)
Project Offset
A fantasy FPS from makers of Savage(which won Indie GOTY 2003)
Alan Wake
A psychological thriller from makers of Max Payne series
Elveon
Unreal Engine 3.0 based RPG from 10Tacle
Blood Bowl
Sports game based on great Games Workshop board game, it will have both traditional turn-based mode as well as real-time one. It's being developed by Cyanide Studios (makers of similar Chaos League
Turning Point: Fall of Liberty
Legendary: The Box
Bionic Commando
Operation Flashpoint 2
The Secret World
A MMO from makers of Age of Conan and Longest Journey franchise
Interstellar Marines
FPS using Unreal Engine 3.0
Totems
Action-adventure from the makers of Outcast
RAGE
Brothers In Arms: Hell's Highway
Splinter Cell 5
Assassins Creed
Command and Conquer 3: Kanes Wrath
Add-on to 9.0 RTS
Agency
Spy-themed action MMO from SOE
Fracture
SF shooter from makers of Mech Assault series
Left 4 Dead
C-op centered Source-based shooter from Turtle Rock and Valve.
Lord of Creatures
Being made by lead designers of Commandos and Commandos2.
The Club
Third person shooter by Bizzare Creations ( makers of Project Gotham Racing series)
Mercenaries 2
Sequel to 8.8 game
Strike Force Red Cell
Commercial follow-up to great UT2004 mod
Rogue Warrior
Unreal Engine 3.0 based tactical shooter
Galtrix
Simple space strategy game made by creators of Warlords franchise
Borderlands
Post apocalyptic shooter from Gearbox (makers of Brothers in Arms series)
Armed Assault 2
Lost
Untitled Junction Point Project
From Warren Spector (creator of Deus Ex)
Precursors
An open ended action/rpg game which takes action in space and on planets(think STALKER mixed with Privateer), from makers of BoilingPoint
Age of Conan
Devil May Cry 4
Commanders: Attack
TUrn-based wargame from Southend Interactive, makers of Deathrow(8.7)
White Gold: War in Paradise
FPS/RPG hybrid that's a successor to Boiling Point. The game changes setting and characters, but keeps the core gameplay concept intact. So we can expect huge dynamic terrain to explore , incredible freedom, tons of stuff to do and developer's ambition that would make most other companies explode 
Kingdom Under Fire: Circle of Doom
Action RPG set in KUF universe(the last two KUF games were both strong AAs at Gamespot)
Necrovision
FPS from Farm21(company created by people who worked on games like Painkiller or MOH: Allied Assault), running on heavily upgraded Painkiller engine
Huxley
A MMO FPS from Webzen running on UE3.0
Alone in the Dark 5
Braid
Winner of IGF 2006 Innovation Award
Everyday Shooter
game nominated for 2007 IGF's Design Innovation, Excellence in Audio and Grand Prize awards
Tentative Multiplatform games:
GTA IV
