The only annoyance I get out of using multiple disk's is that when I want to play Lost Odyssey or Star Ocean, I have to install the game's to my 20 gig 360 hard drive because I can't stand the fan and I always get worried that it could over heat. Otherwise it's fine, I guess.
Bet with Conegamer and AussieGecko that the PS3 will have more exclusives in 2011 than the Wii or 360... or something.