I teared up at various points in various games. Not quite like my wife - the ending of ICO devastated her - but I've done it before.
The ending to Mother 3, though? That destroyed me. I haven't cried like that since I was four years old. I've never been affected by any piece of media like I was by that game.
In fairness I was going through some depression at the time, but the fact remains.
"My poor boy.... You must be so tired...."