Nintendo is going to put an actual release date for Metroid Other M and Super Mario Galaxy 2 for America. They're also going to reveal a new title, possibly tied to the Vitality Sensor. Regardless if the new title is tied to the vitality sensor or not, they will both reveal a new title and reveal more info on the 'Vitality Sensor'. Finally, they're going to announce their support for third party titles outside of Japan (namely Dragon Quest IX and Monster Hunter Tri).
....and Iwata will give a 20 minute presentation about how Nintendo is leading the industry and show graphs.