1. Localization confirmations, particularly with games like Tales of Graces, Last Story, and Zangeki. Also vitality sensor details and possibly some announced games that support it.
2. New games from key franchises like Kirby, Pikmin, Kid Icarus, again the localization of Zangeki, and hopefully some more motion plus games.
3. A new console or handheld, another Wii Sports, Music, Play, Fit, etc..
4. A Zelda Wii trailer, black Wii announcement for America.