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Ι have played both (on XBOX and on XBOX360) and there are considerably many differences and different missions (The HQ missions, the introducing level etc)
If you want to have the full picture play both.
If you don't want to, I'd suggest you stick to the 6th gen version. But I don't know how the game looks on GC. The XBOX version looked spectacular, but the PS2 was shitty.
I guess the GC version, looks more similar to the XBOX one. So, there you have it.