No, I do not believe the game will go on to sell as well as Uncharted 2 or MGS4, but I do believe that it will do well and exceed many people's expectations. The game will definitely be a critical success (as you can see from the reviews that are already pouring in) and this critical success and word of mouth will make sure that the game will do well. Mix this up with a couple of Kevin Butler commercials and I'm sure we have a game that can make some profit. I do not think that the first week will be too hot; I'm estimating about 400K (which is higher than a lot of your expectations) but the following weeks and months will be very steady due to the positive vibe about it. It's something new and I'm sure many consumers will be willing to check this game out. I'm estimating a minimum of 1.5M LTD and it could even cross 2M if the promotional campaign for it is good. Fingers crossed for this title, it will rock!
EDIT: I'm just editing this thread I made a bit before the game's release and almost everyone ridiculed me on my prediction about the game being a success. I predicted 400K first week and 1.5-2 million LTD...although I'm ecstatic that my prediction came true, I'm happier that the game got the success it deserves...HR is truly a remarkable and unique experience from start to finish and deserves all the critical and commercial acclaim it will get, and then some!