Well whenever I watch footage of Heavy Rain, I see some good things in it, some that are better than Uncharted 2, but I also see some bad things in it (same thing I always saw with Killzone 2). It's despite looking good in certain areas, it doesn't look good in all areas. One of the things games like Uncharted 2 prides itself in, is being able to be well polished in all areas. So polished, that the world seems seamless rather than interlocking parts. There are very few games I've seen to have amazing polish, Super Mario Galaxy, Uncharted 2, Crysis, and Okami are a few though. Just takes expertise in development.
So still obviously haven't seen the actual game running on a big screen, but I don't think it'll be able to take the realism crown from Uncharted 2, and obviously not from Crysis. But it is an intriguing different kind of game that will be a refreshing playthrough for many.