My first reaction was DS2, my second was Wii2 (if this is true at all).
Why DS2 - because sales are starting to go down.
Why not DS2 - because they just recently started the DS LL in Japan and haven't even begun selling it anywhere else.
Why Wii2 - because the are starting to run out of major franchises that can seriously push the Wii beyond, say, 2011, and 3rd party support is lessening. Why not Wii2 - because all that said and done, Wii is generally still selling like hotcakes.
Possible scenario - they announce a more expensive Wii2 (with HD and a vitality sensor system) that is completely backwards compatible that will come out around mid-2011. When it comes out, people will have the choice of either buying an (initially) $350 Wii2 or a (then) $150 Wii. Any games you buy for Wii will not be obsolete.
Currently Playing: Shin Megami Tensei: Devil Survivor Overclocked, Professor Layton and the Curious Village
Anticipating: Xenoblade, The Last Story, Mario Kart 7, Rayman Origins, Zelda SS, Crush3D, Tales of the Abyss 3DS, MGS:Snake Eater 3DS, RE:Revelations, Time Travellers, Professor Layton vs. Ace Attorney, Luigi's Mansion 2, MH TriG, DQ Monsters, Heroes of Ruin