I would recommend Little Big Planet as someone else pointed out. That game is hours of fun, and with new content always being added it's not even a "replay" game it's more like a game with a ton of free DLC.
Demon's Souls is another one that was mentioned. I disagree with Folklore though, I got so bored with that game, and I love RPG's.
Fallout 3 and Oblivion were also mentioned, I actually bought both of those games twice for different systems as they were awesome. Also bought Dragon Age: Origins twice as well, once for PS3 and then again for PC so I could play at work lol.
Bioshock is good for at least one second playthrough.
Unicorns ARE real - They are just fat, grey and called Rhinos








