@CrimsonRevolver
I'm working on Darksiders right now. From what I've read there a couple trophies that you can miss and you can't do a new game plus. So make sure to have extra saves before the final boss so you can return to previous areas.
The missable ones are:
1) Aerial Predator: Kill 160 enemies on the angelic beast. (in the one flying section at Echo Gorge)
2) Who's Counting? Defeat more angels than Ulthane. (its tough to miss this one)
3) Open Air Parking: Destroy the helicopter with a car during the apocalypse. (at the beginning of the game)
4) High Flier: Kill 5 Duskbats without touching the ground. (there is a challenge room in the Choking Grounds that is ideal for this one).
5) Improvised Kills: Kill 150 enemies with items from the environment. (better to do earlier on before the enemies get tougher and items in the environment are destroyed).
