You know what? I have both Uncharted 1 and Infamous and I gotta say I like Infamous more. I'm having a blast playing as the good guy (soon I'll start as evil), the gameplay is fantastic. I'm always climbing buildings and riding cables lol. Also, it's cool to have civilians attacking enemies with rocks and it's hilarious the way some girls act when they are close to Cole. I love Uncharted, but inFAMOUS is just a little more fun to me.
That said, I don't think we will see the same fate for infamous 2 the same way we did with Uncharted 2, even though I would like to!