Although I'd love to see Resistance 3 and Killzone 3 I hope they're not the 'big' announcemnts in terms of games at E3 (along with Infamous 2). Hopefully Sony have got a few surprises in store too.
If it's true that they may not launch till 2011 then Sony must surely have something else saved up for holidays 2010? Also interesting that R3 in 2011 would break the Insomniac trend of a game a year. Perhaps they're really going full out on this one to make it as great as possible or maybe they have something to release this year?