It's an interesting question. Not whether it would kill Mario or not, but whether MS or Sony will look at NSMB:Wii sales and think "hey, our consoles could do that too, couldn't they?".
They didn't seem to respond to Mario Kart Wii though, but that's somewhat more dependent on the Wii remote. Maybe they will.
A game I'm developing with some friends:
www.xnagg.com/zombieasteroids/publish.htm
It is largely a technical exercise but feedback is appreciated.