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Metroid became a core franchise thanks to its huge resurgances on the Gamecube.

On every Nintendo system I think you can place titles from these franchises as the stand-out games that people think of when they think of that generation.

For me:

NES: Super Mario Bros (1 or 3?)
SNES: Legend of Zelda: A Link to the Past
N64: Super Mario 64 / Ocarina of Time
Gamecube: Metroid Prime
Wii: Super Mario Galaxy