On the PC its usually the software you're running in the background rather than hardware incompatibility which causes problems. They can't test their game with say AVG antivirus + Radeon 3870 with Catalyst 9.2 for example and that combination may very well prove fatal to the game engine. In a lot of cases its the anti-virus software which causes problems so I suggest at minimum you should disable it and test the game again to see if there are improvements.
Btw I hardly ever have problems with game crashes even with cracks to kill the stupid disc check. So I can happily say there are pretty good chances you can replicate my own systems reliability.
Tease.