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There is a very significant difference from taking calculated risks that enhance the quality of life, and taking moronic risks that are highly likely to degrade the quality of your life. When it comes to playing with "mood altering" drugs, the risks associated with them vary quite widely; something like alcohol or pot is similar in risk to petting a unfamiliar dog in a quiet community, whereas hard drugs like crack-cocaine or crystal-meth are more inline with petting a wild and hungry wolf. I wouldn’t say that drugs like LSD or mushrooms on their own are high risk, but (from what I have seen in my own life) experimentation with these drugs tends to be an early indicator of further experimentation with riskier drugs.